Ontology highlight
ABSTRACT:
SUBMITTER: Kang HS
PROVIDER: S-EPMC2486348 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Kang Hyun-Seo HS Nelson Mary L ML Mackereth Cameron D CD Schärpf Manuela M Graves Barbara J BJ McIntosh Lawrence P LP
Journal of molecular biology 20080130 3
Using NMR spectroscopy, we identified and characterized a previously unrecognized structured domain near the N-terminus (residues 35-121) of the ETS family transcription factor GABP alpha. The monomeric domain folds as a five-stranded beta-sheet crossed by a distorted helix. Although globally resembling ubiquitin, the GABP alpha fragment differs in its secondary structure topology and thus appears to represent a new protein fold that we term the OST (On-SighT) domain. The surface of the GABP alp ...[more]