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Ets transcription factor GABP controls T cell homeostasis and immunity.

ABSTRACT: Peripheral T cells are maintained in the absence of vigorous stimuli, and respond to antigenic stimulation by initiating cell cycle progression and functional differentiation. Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeostasis. In addition, GABP is critically required for antigen-stimulated T-cell responses in vitro and in vivo. Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encoding proteins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases. These findings show that GABP has a nonredundant role in the control of T-cell homeostasis and immunity.

SUBMITTER: Luo CT

PROVIDER: S-EPMC5648787 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Ets transcription factor GABP controls T cell homeostasis and immunity.

Luo Chong T CT Osmanbeyoglu Hatice U HU Do Mytrang H MH Bivona Michael R MR Toure Ahmed A Kang Davina D Xie Yuchen Y Leslie Christina S CS Li Ming O MO

Nature communications 20171020 1

Peripheral T cells are maintained in the absence of vigorous stimuli, and respond to antigenic stimulation by initiating cell cycle progression and functional differentiation. Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeostasis. In addition, GABP is critically required for antigen-stimulated T-cell responses in vitro and in vivo. Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets enc ...[more]

PMID: 29051483

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