Ontology highlight
ABSTRACT:
SUBMITTER: Robert-Moreno A
PROVIDER: S-EPMC2486417 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
The EMBO journal 20080605 13
Specific deletion of Notch1 and RBPjkappa in the mouse results in abrogation of definitive haematopoiesis concomitant with the loss of arterial identity at embryonic stage. As prior arterial determination is likely to be required for the generation of embryonic haematopoiesis, it is difficult to establish the specific haematopoietic role of Notch in these mutants. By analysing different Notch-ligand-null embryos, we now show that Jagged1 is not required for the establishment of the arterial fate ...[more]