Ontology highlight
ABSTRACT:
SUBMITTER: Shutter JR
PROVIDER: S-EPMC316657 | biostudies-literature | 2000 Jun
REPOSITORIES: biostudies-literature
Shutter J R JR Scully S S Fan W W Richards W G WG Kitajewski J J Deblandre G A GA Kintner C R CR Stark K L KL
Genes & development 20000601 11
We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand, characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding. In situ analysis reveals a highly selective expression pattern of Dll4 within the vascular endothelium. The activity and expression of Dll4 and the known actions of other memb ...[more]