S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity.
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ABSTRACT:
SUBMITTER: Tian J
PROVIDER: S-EPMC2492460 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity.
Tian Jing J Kim Sangwon F SF Hester Lynda L Snyder Solomon H SH
Proceedings of the National Academy of Sciences of the United States of America 20080723 30
Glutamate/N-methyl-d-aspartate (NMDA) receptor-mediated neurotoxicity involves cyclooxygenase (COX)-2. We demonstrate that this neurotoxicity reflects activation of COX-2 by S-nitrosylation after selective binding of neuronal nitric oxide synthase (nNOS) to COX-2. nNOS, via its PDZ domain, binds COX-2 with the generated NO S-nitrosylating and activating the enzyme. Selective disruption of nNOS-COX-2 binding prevents NMDA neurotoxicity. ...[more]
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