Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC2493356 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Yang Jianhua J Kim Kevin D KD Lucas Andrew A Drahos Karen E KE Santos Carlo S CS Mury Sean P SP Capelluto Daniel G S DG Finkielstein Carla V CV
Molecular and cellular biology 20080527 15
Although efforts have been made to identify circadian-controlled genes regulating cell cycle progression and cell death, little is known about the metabolic signals modulating circadian regulation of gene expression. We identify heme, an iron-containing prosthetic group, as a regulatory ligand controlling human Period-2 (hPer2) stability. Furthermore, we define a novel heme-regulatory motif within the C terminus of hPer2 (SC(841)PA) as necessary for heme binding and protein destabilization. Spec ...[more]