Ontology highlight
ABSTRACT:
SUBMITTER: Lupu F
PROVIDER: S-EPMC2495767 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Lupu Floria F Alves Annabelle A Anderson Kathryn K Doye Valérie V Lacy Elizabeth E
Developmental cell 20080601 6
Serving as the primary conduit for communication between the nucleus and the cytoplasm, nuclear pore complexes (NPCs) impact nearly every cellular process. The extent to which NPC composition varies and the functional significance of such variation in mammalian development has not been investigated. Here we report that a null allele of mouse nucleoporin Nup133, a structural subunit of the NPC, disrupts neural differentiation. We find that expression of Nup133 is cell type and developmental stage ...[more]