Ontology highlight
ABSTRACT:
SUBMITTER: Roder G
PROVIDER: S-EPMC2496847 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Røder Gustav G Kristensen Ole O Kastrup Jette S JS Buus Søren S Gajhede Michael M
Acta crystallographica. Section F, Structural biology and crystallization communications 20080517 Pt 6
The human leukocyte antigen (HLA) class I system comprises a highly polymorphic set of molecules that specifically bind and present peptides to cytotoxic T cells. HLA-B*1501 is a prototypical member of the HLA-B62 supertype and only two peptide-HLA-B*1501 structures have been determined. Here, the crystal structure of HLA-B*1501 in complex with a SARS coronavirus-derived nonapeptide (VQQESSFVM) has been determined at high resolution (1.87 A). The peptide is deeply anchored in the B and F pockets ...[more]