Ontology highlight
ABSTRACT:
SUBMITTER: Yin L
PROVIDER: S-EPMC4156084 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Yin Liusong L Trenh Peter P Guce Abigail A Wieczorek Marek M Lange Sascha S Sticht Jana J Jiang Wei W Bylsma Marissa M Mellins Elizabeth D ED Freund Christian C Stern Lawrence J LJ
The Journal of biological chemistry 20140707 34
HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen presentation by a mechanism that remains unclear and controversial. Here, we investigated the sequence and structural determinants of HLA-DM interaction. Peptides interacting nonoptimally in the P1 pocket exhibited low MHCII binding affinity and kinetic instability and were highly susceptible to HLA-DM-mediated peptide exchange. These changes were accompanied by conformational alterations detected by surface plas ...[more]