Ontology highlight
ABSTRACT:
SUBMITTER: Hong X
PROVIDER: S-EPMC2499998 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Hong Xin X Jiang Feng F Kalkanis Steven N SN Zhang Zheng Gang ZG Zhang Xuepeng X Zheng Xuguang X Jiang Hao H Mikkelsen Tom T Chopp Michael M
Journal of experimental & clinical cancer research : CR 20080722
Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix (ECM) and basement membrane. Expression of the heparanase gene is associated with the invasion and metastatic potential of a variety of tumor-derived cell types. However, the roles of heparanase in the regulation of gene expression and the subsequent cell function changes other than invasion are not clear. In the current study, we overexpressed the human heparanase gene ...[more]