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Serotonin modulates behavioral reactions to unfairness.

ABSTRACT: Serotonin (5-HT) has long been implicated in social behavior and impulsivity, but the mechanisms through which it modulates self-control remain unclear. We observed the effects of manipulating 5-HT function on behavior in the ultimatum game, where players must decide whether to accept or reject fair or unfair monetary offers from another player. Participants with depleted 5-HT levels rejected a greater proportion of unfair offers, but not fair offers, without showing changes in mood, fairness judgment, basic reward processing, or response inhibition. Our results suggest that 5-HT plays a critical role in regulating emotion during social decision-making.

SUBMITTER: Crockett MJ

PROVIDER: S-EPMC2504725 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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Serotonin modulates behavioral reactions to unfairness.

Crockett Molly J MJ Clark Luke L Tabibnia Golnaz G Lieberman Matthew D MD Robbins Trevor W TW

Science (New York, N.Y.) 20080605 5884

Serotonin (5-HT) has long been implicated in social behavior and impulsivity, but the mechanisms through which it modulates self-control remain unclear. We observed the effects of manipulating 5-HT function on behavior in the ultimatum game, where players must decide whether to accept or reject fair or unfair monetary offers from another player. Participants with depleted 5-HT levels rejected a greater proportion of unfair offers, but not fair offers, without showing changes in mood, fairness ju ...[more]

PMID: 18535210

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