Ontology highlight
ABSTRACT:
SUBMITTER: Cooper GM
PROVIDER: S-EPMC2515139 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Cooper Gregory M GM Johnson Julie A JA Langaee Taimour Y TY Feng Hua H Stanaway Ian B IB Schwarz Ute I UI Ritchie Marylyn D MD Stein C Michael CM Roden Dan M DM Smith Joshua D JD Veenstra David L DL Rettie Allan E AE Rieder Mark J MJ
Blood 20080605 4
Warfarin dosing is correlated with polymorphisms in vitamin K epoxide reductase complex 1 (VKORC1) and the cytochrome P450 2C9 (CYP2C9) genes. Recently, the FDA revised warfarin labeling to raise physician awareness about these genetic effects. Randomized clinical trials are underway to test genetically based dosing algorithms. It is thus important to determine whether common single nucleotide polymorphisms (SNPs) in other gene(s) have a large effect on warfarin dosing. A retrospective genome-wi ...[more]