Genome-wide association study of warfarin maintenance dose in a Brazilian sample.
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ABSTRACT:
SUBMITTER: Parra EJ
PROVIDER: S-EPMC4573240 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Genome-wide association study of warfarin maintenance dose in a Brazilian sample.
Parra Esteban J EJ Botton Mariana R MR Perini Jamila A JA Krithika S S Bourgeois Stephane S Johnson Todd A TA Tsunoda Tatsuhiko T Pirmohamed Munir M Wadelius Mia M Limdi Nita A NA Cavallari Larisa H LH Burmester James K JK Rettie Allan E AE Klein Teri E TE Johnson Julie A JA Hutz Mara H MH Suarez-Kurtz Guilherme G
Pharmacogenomics 20150812 11
<h4>Aim</h4>Extreme discordant phenotype and genome-wide association (GWA) approaches were combined to explore the role of genetic variants on warfarin dose requirement in Brazilians.<h4>Methods</h4>Patients receiving low (≤ 20 mg/week; n = 180) or high stable warfarin doses (≥ 42.5 mg/week; n = 187) were genotyped with Affymetrix Axiom(®) Biobank arrays. Imputation was carried out using data from the combined 1000 Genomes project.<h4>Results</h4>Genome-wide signals (p ≤ 5 × 10(-8)) were identif ...[more]
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