Ontology highlight
ABSTRACT:
SUBMITTER: Minard-Colin V
PROVIDER: S-EPMC2515149 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Minard-Colin Veronique V Xiu Yan Y Poe Jonathan C JC Horikawa Mayuka M Magro Cynthia M CM Hamaguchi Yasuhito Y Haas Karen M KM Tedder Thomas F TF
Blood 20080521 4
Despite the demonstrated clinical efficacy of CD20 monoclonal antibody (mAb) for lymphoma therapy, the in vivo mechanisms of tumor depletion remain controversial and variable. To identify the molecular mechanisms responsible for lymphoma killing by CD20 mAb in a homologous system amenable to mechanistic studies and genetic manipulation, a mouse lymphoma model was developed using primary tumor cells from a C57BL/6 Emicro-cMyc transgenic mouse and mouse antimouse CD20 mAbs. CD20 mAb treatment of s ...[more]