Ontology highlight
ABSTRACT:
SUBMITTER: Bergeron RJ
PROVIDER: S-EPMC2516204 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Bergeron Raymond J RJ Wiegand Jan J McManis James S JS Bharti Neelam N
Journal of medicinal chemistry 20061101 24
A series of iron chelators, three (S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-methyl-4-thiazolecarboxylic acid (DADFT) and three (S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-thiazolecarboxylic acid (DADMDFT) analogues are synthesized and assessed for their lipophilicity (log Papp), iron-clearing efficiency (ICE) in rodents and iron-loaded primates (Cebus apella), toxicity in rodents, and organ distribution in rodents. The results lead to a number of generalizations useful in chelator design strategies. In ro ...[more]