Ontology highlight
ABSTRACT:
SUBMITTER: Coquet JM
PROVIDER: S-EPMC2516267 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Coquet Jonathan M JM Chakravarti Sumone S Kyparissoudis Konstantinos K McNab Finlay W FW Pitt Lauren A LA McKenzie Brent S BS Berzins Stuart P SP Smyth Mark J MJ Godfrey Dale I DI
Proceedings of the National Academy of Sciences of the United States of America 20080806 32
NKT cell subsets can be divided based on CD4 and NK1.1 expression and tissue of origin, but the developmental and functional relationships between the different subsets still are poorly understood. A comprehensive study of 19 cytokines across different NKT cell subsets revealed that no two NKT subpopulations exhibited the same cytokine profile, and, remarkably, the amounts of each cytokine produced varied by up to 100-fold or more among subsets. This study also revealed the existence of a popula ...[more]