Unknown

Dataset Information

0

Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population.

ABSTRACT: NKT cell subsets can be divided based on CD4 and NK1.1 expression and tissue of origin, but the developmental and functional relationships between the different subsets still are poorly understood. A comprehensive study of 19 cytokines across different NKT cell subsets revealed that no two NKT subpopulations exhibited the same cytokine profile, and, remarkably, the amounts of each cytokine produced varied by up to 100-fold or more among subsets. This study also revealed the existence of a population of CD4(-)NK1.1(-) NKT cells that produce high levels of the proinflammatory cytokine IL-17 within 2-3 h of activation. On intrathymic transfer these cells develop into mature CD4(-)NK1.1(+) but not into CD4(+)NK1.1(+) NKT cells, indicating that CD4(-)NK1.1(-) NKT cells include an IL-17-producing subpopulation, and also mark the elusive branch point for CD4(+) and CD4(-) NKT cell sublineages.

SUBMITTER: Coquet JM 

PROVIDER: S-EPMC2516267 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population.

Coquet Jonathan M JM   Chakravarti Sumone S   Kyparissoudis Konstantinos K   McNab Finlay W FW   Pitt Lauren A LA   McKenzie Brent S BS   Berzins Stuart P SP   Smyth Mark J MJ   Godfrey Dale I DI  

Proceedings of the National Academy of Sciences of the United States of America 20080806 32

NKT cell subsets can be divided based on CD4 and NK1.1 expression and tissue of origin, but the developmental and functional relationships between the different subsets still are poorly understood. A comprehensive study of 19 cytokines across different NKT cell subsets revealed that no two NKT subpopulations exhibited the same cytokine profile, and, remarkably, the amounts of each cytokine produced varied by up to 100-fold or more among subsets. This study also revealed the existence of a popula  ...[more]

Similar Datasets

Unknown CD4 T cells play important roles in maintaining IL-17-producing ?? T-cell subsets in naive animals.
| S-EPMC3170686 | biostudies-other
Unknown Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia.
| S-EPMC2118594 | biostudies-literature
Unknown ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells.
| S-EPMC3515659 | biostudies-literature
Unknown CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression.
| S-EPMC7430972 | biostudies-literature
Unknown Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production.
| S-EPMC2799849 | biostudies-literature
Unknown Human IL-10-producing B cells have diverse states that are induced from multiple B cell subsets.
| S-EPMC9107325 | biostudies-literature
Unknown The Clinical Relevance of IL-17-Producing CD4+CD161+ Cell and Its Subpopulations in Primary Sjogren's Syndrome.
| S-EPMC4578753 | biostudies-literature
Unknown Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
| S-EPMC3149619 | biostudies-literature
Unknown Adoptively transferred donor IL-17-producing CD4<sup>+</sup> T cells augment, but IL-17 alleviates, acute graft-versus-host disease.
| S-EPMC5843609 | biostudies-literature
Unknown Adiponectin Limits IFN-γ and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis.
| S-EPMC6828851 | biostudies-literature