Ontology highlight
ABSTRACT:
SUBMITTER: Surendar J
PROVIDER: S-EPMC6828851 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Surendar Jayagopi J Frohberger Stefan J SJ Karunakaran Indulekha I Schmitt Vanessa V Stamminger Wiebke W Neumann Anna-Lena AL Wilhelm Christoph C Hoerauf Achim A Hübner Marc P MP
Frontiers in immunology 20191029
Compared to the innate immune system, the contribution of the adaptive immune response during obesity and insulin resistance is still not completely understood. Here we demonstrate that high fat diet (HFD) increases the frequencies of activated CD4+ and CD8+ T cells and frequencies of T cells positive for IFN-γ and IL-17 in the adipose tissue. The adipocyte-derived soluble factor adiponectin reduces IFN-γ and IL-17 positive CD4+ T cells from HFD mice and dampens the differentiation of naïve T ce ...[more]