Mechanisms of sepsis and insights from clinical trials.
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ABSTRACT:
SUBMITTER: Seam N
PROVIDER: S-EPMC2516940 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Publications
Mechanisms of sepsis and insights from clinical trials.
Seam Nitin N Suffredini Anthony F AF
Drug discovery today. Disease mechanisms 20070101 2
Multiple clinical trials of adjunctive therapy for sepsis and septic shock have been conducted to neutralize bacterial components or to modulate host inflammatory responses to infection but with limited success. Many therapies are only beneficial only in patients with a high severity of illness and have minimal or harmful effects in patients that are less severely ill. Improved measures of severity of illness and discovery of biomarkers to help identify these high-risk patients are needed. ...[more]
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