Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC6379961 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Molecular cancer 20190219 1
Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important intracellular pathways, which can be considered as a master regulator for cancer. Enormous efforts have been dedicated to the development of drugs targeting PI3K signaling, many of which are currently employed in clinical trials evaluation, and it is becoming increasingly clear that PI3K inhibitors are effective in inhibiting tumor progression. PI3K inhibitors are subdivided into ...[more]