Ontology highlight
ABSTRACT:
SUBMITTER: Lee KF
PROVIDER: S-EPMC2517609 | biostudies-literature | 2008 May-Jun
REPOSITORIES: biostudies-literature
Lee K F Eddy KF Salvaris Evelyn J EJ Roussel Jean-Christian JC Robson Simon C SC d'Apice Anthony J F AJ Cowan Peter J PJ
Xenotransplantation 20080501 3
Rejected pig-to-primate organ xenografts almost invariably exhibit significant microvascular thrombosis, believed to be due in part to several molecular incompatibilities affecting the regulation of coagulation. In this study, we tested one such proposed incompatibility: whether there is, at least in part, a functional incompatibility in pig tissue factor pathway inhibitor (TFPI) that impedes binding of human factor Xa and regulation of human tissue factor-initiated coagulation. TFPIalpha cDNA w ...[more]