Ontology highlight
ABSTRACT:
SUBMITTER: Rajalingam K
PROVIDER: S-EPMC2518856 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Rajalingam Krishnaraj K Sharma Manu M Lohmann Christine C Oswald Monique M Thieck Oliver O Froelich Christopher J CJ Rudel Thomas T
PloS one 20080901 9
Chlamydia are obligate intracellular bacteria that cause variety of human diseases. Host cells infected with Chlamydia are protected against many different apoptotic stimuli. The induction of apoptosis resistance is thought to be an important immune escape mechanism allowing Chlamydia to replicate inside the host cell. Infection with C. trachomatis activates the Raf/MEK/ERK pathway and the PI3K/AKT pathway. Here we show that inhibition of these two pathways by chemical inhibitors sensitized C. t ...[more]