Ontology highlight
ABSTRACT:
SUBMITTER: Rajalingam K
PROVIDER: S-EPMC1626104 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Rajalingam Krishnaraj K Sharma Manu M Paland Nicole N Hurwitz Robert R Thieck Oliver O Oswald Monique M Machuy Nikolaus N Rudel Thomas T
PLoS pathogens 20061001 10
Host cells infected with obligate intracellular bacteria Chlamydia trachomatis are profoundly resistant to diverse apoptotic stimuli. The molecular mechanisms underlying the block in apoptotic signaling of infected cells is not well understood. Here we investigated the molecular mechanism by which apoptosis induced via the tumor necrosis factor (TNF) receptor is prevented in infected epithelial cells. Infection with C. trachomatis leads to the up-regulation of cellular inhibitor of apoptosis (cI ...[more]