A starvation-induced noncoding RNA modulates expression of Dicer-regulated genes.
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ABSTRACT:
SUBMITTER: Hellwig S
PROVIDER: S-EPMC2519042 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
A starvation-induced noncoding RNA modulates expression of Dicer-regulated genes.
Hellwig Sabine S Bass Brenda L BL
Proceedings of the National Academy of Sciences of the United States of America 20080822 35
Although much has been learned about short noncoding RNAs, long noncoding transcripts are largely uncharacterized. Here, we describe Caenorhabditis elegans rncs-1, a highly base-paired, 800-nucleotide noncoding RNA expressed in hypodermis and intestine. Transcription of rncs-1 is modulated in response to food supply. Although highly double-stranded, we show that rncs-1 RNA is not a substrate for Dicer because of branched structures at its termini. However, rncs-1 RNA inhibits Dicer cleavage of a ...[more]
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