Ontology highlight
ABSTRACT:
SUBMITTER: Overhage J
PROVIDER: S-EPMC2519444 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Overhage Joerg J Campisano Andrea A Bains Manjeet M Torfs Ellen C W EC Rehm Bernd H A BH Hancock Robert E W RE
Infection and immunity 20080630 9
The ability to form biofilms is a critical factor in chronic infections by Pseudomonas aeruginosa and has made this bacterium a model organism with respect to biofilm formation. This study describes a new, previously unrecognized role for the human cationic host defense peptide LL-37. In addition to its key role in modulating the innate immune response and weak antimicrobial activity, LL-37 potently inhibited the formation of bacterial biofilms in vitro. This occurred at the very low and physiol ...[more]