Ontology highlight
ABSTRACT:
SUBMITTER: Youdell ML
PROVIDER: S-EPMC2519698 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Youdell Michael L ML Kizer Kelby O KO Kisseleva-Romanova Elena E Fuchs Stephen M SM Duro Eris E Strahl Brian D BD Mellor Jane J
Molecular and cellular biology 20080609 16
Set2 (KMT3)-dependent methylation (me) of histone H3 at lysine 36 (H3K36) promotes deacetylation of transcribed chromatin and represses cryptic promoters within genes. Although Set2 is the only methyltransferase (KMTase) for H3K36 in yeast, it is not known if Set2 is regulated or whether the different methylation states at H3K36 are functionally distinct. Here we show that the N-terminal 261 residues of Set2 (Set2(1-261)), containing the SET KMTase domain, are sufficient for H3K36me2, histone de ...[more]