Ontology highlight
ABSTRACT:
SUBMITTER: Salzler HR
PROVIDER: S-EPMC9977188 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Salzler Harmony R HR Vandadi Vasudha V McMichael Benjamin D BD Brown John C JC Boerma Sally A SA Leatham-Jensen Mary P MP Adams Kirsten M KM Meers Michael P MP Simon Jeremy M JM Duronio Robert J RJ McKay Daniel J DJ Matera A Gregory AG
Science advances 20230301 9
Polycomb complexes regulate cell type-specific gene expression programs through heritable silencing of target genes. Trimethylation of histone H3 lysine 27 (H3K27me3) is essential for this process. Perturbation of H3K36 is thought to interfere with H3K27me3. We show that mutants of <i>Drosophila</i> replication-dependent (<i>H3.2<sup>K36R</sup></i>) or replication-independent (<i>H3.3<sup>K36R</sup></i>) histone H3 genes generally maintain Polycomb silencing and reach later stages of development ...[more]