Ontology highlight
ABSTRACT:
SUBMITTER: Lemoine FJ
PROVIDER: S-EPMC2519721 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Lemoine Francene J FJ Degtyareva Natasha P NP Kokoska Robert J RJ Petes Thomas D TD
Molecular and cellular biology 20080630 17
Specific regions of genomes (fragile sites) are hot spots for the chromosome rearrangements that are associated with many types of cancer cells. Understanding the molecular mechanisms regulating the stability of chromosome fragile sites, therefore, has important implications in cancer biology. We previously identified two chromosome fragile sites in Saccharomyces cerevisiae that were induced in response to the reduced expression of Pol1p, the catalytic subunit of DNA polymerase alpha. In the stu ...[more]