Ontology highlight
ABSTRACT:
SUBMITTER: Gwack Y
PROVIDER: S-EPMC2519726 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Gwack Yousang Y Srikanth Sonal S Oh-Hora Masatsugu M Hogan Patrick G PG Lamperti Edward D ED Yamashita Megumi M Gelinas Curtis C Neems Daniel S DS Sasaki Yoshiteru Y Feske Stefan S Prakriya Murali M Rajewsky Klaus K Rao Anjana A
Molecular and cellular biology 20080630 17
ORAI1 is a pore subunit of the store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption of the Orai1 gene. The results of immunohistochemical analysis showed that ORAI1 is expressed in lymphocytes, skin, and muscle of wild-type mice and is not expressed in Orai1(-/-) mice. Orai1(-/-) mice with the inbred C57BL/6 background showed perinatal lethality, which was overcome by crossing them ...[more]