Ontology highlight
ABSTRACT:
SUBMITTER: Sinsimer KS
PROVIDER: S-EPMC2519747 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Sinsimer Kristina S KS Gratacós Frances M FM Knapinska Anna M AM Lu Jiebo J Krause Christopher D CD Wierzbowski Alexandria V AV Maher Lauren R LR Scrudato Shannon S Rivera Yonaira M YM Gupta Swati S Turrin Danielle K DK De La Cruz Mary Pauline MP Pestka Sidney S Brewer Gary G
Molecular and cellular biology 20080623 17
Controlled, transient cytokine production by monocytes depends heavily upon rapid mRNA degradation, conferred by 3' untranslated region-localized AU-rich elements (AREs) that associate with RNA-binding proteins. The ARE-binding protein AUF1 forms a complex with cap-dependent translation initiation factors and heat shock proteins to attract the mRNA degradation machinery. We refer to this protein assembly as the AUF1- and signal transduction-regulated complex, ASTRC. Rapid degradation of ARE-bear ...[more]