Ontology highlight
ABSTRACT:
SUBMITTER: Chou CF
PROVIDER: S-EPMC1489004 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Chou Chu-Fang CF Mulky Alok A Maitra Sushmit S Lin Wei-Jye WJ Gherzi Roberto R Kappes John J Chen Ching-Yi CY
Molecular and cellular biology 20060501 10
Inherently unstable mRNAs contain AU-rich elements (AREs) in their 3' untranslated regions that act as mRNA stability determinants by interacting with ARE-binding proteins (ARE-BPs). We have destabilized two mRNAs by fusing sequence-specific RNA-binding proteins to KSRP, a decay-promoting ARE-BP, in a tethering assay. These results support a model that KSRP recruits mRNA decay machinery/factors to elicit decay. The ability of tethered KSRP to elicit mRNA decay depends on functions of known mRNA ...[more]