Ontology highlight
ABSTRACT:
SUBMITTER: Peroutka RJ
PROVIDER: S-EPMC2525526 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Peroutka Raymond J RJ Elshourbagy Nabil N Piech Tara T Butt Tauseef R TR
Protein science : a publication of the Protein Society 20080606 9
SUMOylation, the covalent attachment of SUMO (small ubiquitin-like modifier), is a eukaryotic post-translational event that has been demonstrated to play a critical role in several biological processes. When used as an N-terminal tag or fusion partner, SUMO has been shown to enhance functional protein production significantly by improving folding, solubility, and stability. We have engineered several SUMOs and, through their fusion, developed a system for enhancing the expression and secretion o ...[more]