Ontology highlight
ABSTRACT:
SUBMITTER: Yui D
PROVIDER: S-EPMC4670075 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yui Daishi D Nishida Yoichiro Y Nishina Tomoko T Mogushi Kaoru K Tajiri Mio M Ishibashi Satoru S Ajioka Itsuki I Ishikawa Kinya K Mizusawa Hidehiro H Murayama Shigeo S Yokota Takanori T
PloS one 20151204 12
Oxidative stress has a ubiquitous role in neurodegenerative diseases and oxidative damage in specific regions of the brain is associated with selective neurodegeneration. We previously reported that Alzheimer disease (AD) model mice showed decreased insulin-degrading enzyme (IDE) levels in the cerebrum and accelerated phenotypic features of AD when crossbred with alpha-tocopherol transfer protein knockout (Ttpa-/-) mice. To further investigate the role of chronic oxidative stress in AD pathophys ...[more]