Unknown

Dataset Information

0

Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.


ABSTRACT: We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and that all IL-17-producing cells are contained in the CD161(+) fraction of CD4(+) T cells present in the circulation or in inflamed tissues, although they are not CD1-restricted natural killer T cells. More importantly, we show that all IL-17-producing cells originate from CD161(+) naive CD4(+) T cells of umbilical cord blood, as well as of the postnatal thymus, in response to the combined activity of IL-1 beta and IL-23. These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor.

SUBMITTER: Cosmi L 

PROVIDER: S-EPMC2525581 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications


We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and that all IL-17-producing cells are contained in the CD161(+) fraction of CD4(+) T cells present in the circulation or in inflamed tissues, although they are not CD1-restricted natural killer T cells. More importantly, we show that all IL-17-producing cells originate from CD161(+) naive CD4(+) T cells of umbilical cord blood, as well as of the postnatal thymus, in response to the c  ...[more]

Similar Datasets

| S-EPMC4578753 | biostudies-literature
| S-EPMC6249057 | biostudies-literature
| S-EPMC1618871 | biostudies-literature
| S-EPMC3491488 | biostudies-literature
| S-EPMC5374100 | biostudies-literature
| S-EPMC2799849 | biostudies-literature
| S-EPMC2563129 | biostudies-literature
| S-EPMC4123443 | biostudies-literature
2012-07-11 | E-GEOD-22877 | biostudies-arrayexpress
2012-07-12 | GSE22877 | GEO