Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing ?? cells.

ABSTRACT: IL-17-producing CD27(-) ?? cells (??(27-) cells) are widely viewed as innate immune cells that make critical contributions to host protection and autoimmunity. However, factors that promote them over IFN-?-producing ??(27+) cells are poorly elucidated. Moreover, although human IL-17-producing ?? cells are commonly implicated in inflammation, such cells themselves have proved difficult to isolate and characterize. Here, murine ??(27-) T cells and thymocytes are shown to be rapidly and substantially expanded by IL-7 in vitro and in vivo. This selectivity owes in substantial part to the capacity of IL-7 to activate STAT3 in such cells. Additionally, IL-7 promotes strong responses of IL-17-producing ?? cells to TCR agonists, thus reemphasizing the cells' adaptive and innate potentials. Moreover, human IL-17-producing ?? cells are also substantially expanded by IL-7 plus TCR agonists. Hence, IL-7 has a conserved potential to preferentially regulate IL-17-producing ?? cells, with both biological and clinical implications.

SUBMITTER: Michel ML 

PROVIDER: S-EPMC3491488 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature