Ontology highlight
ABSTRACT:
SUBMITTER: Nishikii H
PROVIDER: S-EPMC2525582 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Nishikii Hidekazu H Eto Koji K Tamura Noriko N Hattori Koichi K Heissig Beate B Kanaji Taisuke T Sawaguchi Akira A Goto Shinya S Ware Jerry J Nakauchi Hiromitsu H
The Journal of experimental medicine 20080728 8
Embryonic stem cells (ESCs) could potentially compensate for the lack of blood platelets available for use in transfusions. Here, we describe a new method for generating mouse ESC-derived platelets (ESPs) that can contribute to hemostasis in vivo. Flow cytometric sorting of cells from embryoid bodies on day 6 demonstrated that c-Kit(+) integrin alpha IIb (alpha IIb)(+) cells, but not CD31(+) cells or vascular endothelial cadherin(+) cells, are capable of megakaryopoiesis and the release of plate ...[more]