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Organocatalytic highly enantioselective synthesis of secondary alpha-hydroxyphosphonates.


ABSTRACT: [reaction: see text] The first organocatalytic cross aldol reaction of ketones and diethyl formylphosphonate hydrate has been realized by using readily available l-prolinamide as the catalyst. Secondary alpha-hydroxyphosphonates have been synthesized in high enantioselective (up to >99% ee) and good diastereoselectivity.

SUBMITTER: Dodda R 

PROVIDER: S-EPMC2525621 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature

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Organocatalytic highly enantioselective synthesis of secondary alpha-hydroxyphosphonates.

Dodda Rajasekhar R   Zhao Cong-Gui CG  

Organic letters 20061001 21


[reaction: see text] The first organocatalytic cross aldol reaction of ketones and diethyl formylphosphonate hydrate has been realized by using readily available l-prolinamide as the catalyst. Secondary alpha-hydroxyphosphonates have been synthesized in high enantioselective (up to >99% ee) and good diastereoselectivity. ...[more]

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