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Organocatalytic enantioselective synthesis of alpha-hydroxy phosphonates.

ABSTRACT: Tertiary alpha-hydroxy phosphonates have been synthesized in good yields and high enantiomeric purity (up to 99% ee) through a novel l-proline-catalyzed cross aldol reaction of alpha-keto phosphonates and ketones.

SUBMITTER: Samanta S

PROVIDER: S-EPMC2535926 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

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Organocatalytic enantioselective synthesis of alpha-hydroxy phosphonates.

Samanta Sampak S Zhao Cong-Gui CG

Journal of the American Chemical Society 20060601 23

Tertiary alpha-hydroxy phosphonates have been synthesized in good yields and high enantiomeric purity (up to 99% ee) through a novel l-proline-catalyzed cross aldol reaction of alpha-keto phosphonates and ketones. ...[more]

PMID: 16756289

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