Ontology highlight
ABSTRACT:
SUBMITTER: Nakagawa-Goto K
PROVIDER: S-EPMC2526252 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20070615 14
Desmosdumotin C (1) and its analogs previously showed potent, selective in vitro anticancer activity. To explore structure-activity relationships of 1 and further increase potency and selectivity, 15 novel analogs (7-15 and 21-26) were synthesized and evaluated for cytotoxity against several human tumor cell lines, as well as inhibition of human endothelial (HUVEC) replication. 4-Bromo-3',3',5'-tripropyl analog 26 showed significant cytotoxity against A549, A431, 1A9, and HCT-8 with ED50 values ...[more]