Ontology highlight
ABSTRACT:
SUBMITTER: Somu RV
PROVIDER: S-EPMC2526467 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Somu Ravindranadh V RV Wilson Daniel J DJ Bennett Eric M EM Boshoff Helena I HI Celia Laura L Beck Brian J BJ Barry Clifton E CE Aldrich Courtney C CC
Journal of medicinal chemistry 20061201 26
Tuberculosis is the leading cause of infectious disease mortality in the world by a bacterial pathogen. We previously demonstrated that a bisubstrate inhibitor of the adenylation enzyme MbtA, which is responsible for the second step of mycobactin biosynthesis, exhibited potent antitubercular activity. Here we systematically investigate the structure-activity relationships of the bisubstrate inhibitor glycosyl domain resulting in the identification of a carbocyclic analogue that possesses a KIapp ...[more]