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Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors.

ABSTRACT: A screen of indole-based structures revealed the natural product brassinin to be a moderate inhibitor of indoleamine 2,3-dioxygenase (IDO), a new cancer immunosuppression target. A structure-activity study was undertaken to determine which elements of the brassinin structure could be modified to enhance potency. Three important discoveries have been made, which will impact future IDO inhibitor development: (i) The dithiocarbamate portion of the brassinin lead is a crucial moiety, which may be binding to the heme iron of IDO; (ii) an indole ring is not necessary for IDO inhibition; and (iii) substitution of the S-methyl group of brassinin with large aromatic groups provides inhibitors that are three times more potent in vitro than the most commonly used IDO inhibitor, 1-methyl-tryptophan.

SUBMITTER: Gaspari P

PROVIDER: S-EPMC2527235 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature

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Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors.

Gaspari Paul P Banerjee Tinku T Malachowski William P WP Muller Alexander J AJ Prendergast George C GC DuHadaway James J Bennett Shauna S Donovan Ashley M AM

Journal of medicinal chemistry 20060101 2

A screen of indole-based structures revealed the natural product brassinin to be a moderate inhibitor of indoleamine 2,3-dioxygenase (IDO), a new cancer immunosuppression target. A structure-activity study was undertaken to determine which elements of the brassinin structure could be modified to enhance potency. Three important discoveries have been made, which will impact future IDO inhibitor development: (i) The dithiocarbamate portion of the brassinin lead is a crucial moiety, which may be bi ...[more]

PMID: 16420054

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