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Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors.

ABSTRACT: In this study, a series of novel hydroxyamidine derivatives were identified as potent and selective IDO1 inhibitors by structure-based drug design. Among them, compounds 13-15 and 18 exhibited favorable enzymatic and cellular activities. Compound 18 showed improved bioavailability in mouse, rat, and dog (F% = 44%, 58.8%, 102.1%, respectively). With reasonable in vivo pharmacokinetic properties, compound 18 was further evaluated in a transgenic MC38 xenograft mouse model. The combination of compound 18 with PD-1 monoclonal antibody showed a synergistic antitumor effect. These data indicated that compound 18 as a potential cancer immunotherapy agent should warrant further investigation.

SUBMITTER: Jin F

PROVIDER: S-EPMC7883375 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors.

Jin Fangfang F Hu Qiyue Q Fei Hongbo H Lv Hejun H Wang Shenglan S Gui Bin B Zhang Junzhen J Tu Wangyang W Zhang Yun Y Zhang Lei L Wan Hong H Zhang Limin L Hu Bin B Yang Fanglong F Bai Chang C He Feng F Zhang Lianshan L Tao Weikang W

ACS medicinal chemistry letters 20210120 2

In this study, a series of novel hydroxyamidine derivatives were identified as potent and selective IDO1 inhibitors by structure-based drug design. Among them, compounds 13-15 and 18 exhibited favorable enzymatic and cellular activities. Compound 18 showed improved bioavailability in mouse, rat, and dog (F% = 44%, 58.8%, 102.1%, respectively). With reasonable in vivo pharmacokinetic properties, compound 18 was further evaluated in a transgenic MC38 xenog ...[more]

PMID: 33603965

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