Ontology highlight
ABSTRACT:
SUBMITTER: Naganawa S
PROVIDER: S-EPMC2527523 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Naganawa Satoshi S Yokoyama Masaru M Shiino Teiichiro T Suzuki Takeyuki T Ishigatsubo Yoshiaki Y Ueda Atsuhisa A Shirai Akira A Takeno Mitsuhiro M Hayakawa Satoshi S Sato Shigehiro S Tochikubo Osamu O Kiyoura Shingo S Sawada Kaori K Ikegami Takashi T Kanda Tadahito T Kitamura Katsuhiko K Sato Hironori H
PloS one 20080912 9
The third variable region (V3) of the human immunodeficiency virus type 1 (HIV-1) envelope gp120 subunit participates in determination of viral infection coreceptor tropism and host humoral immune responses. Positive charge of the V3 plays a key role in determining viral coreceptor tropism. Here, we examined by bioinformatics, experimental, and protein modelling approaches whether the net positive charge of V3 sequence regulates viral sensitivity to humoral immunity. We chose HIV-1 CRF01_AE stra ...[more]