Interactions of the sweet protein brazzein with the sweet taste receptor.
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ABSTRACT:
SUBMITTER: Walters DE
PROVIDER: S-EPMC2527743 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Publications
Interactions of the sweet protein brazzein with the sweet taste receptor.
Walters D Eric DE Hellekant Göran G
Journal of agricultural and food chemistry 20061201 26
Brazzein is a small, potently sweet protein. Homology modeling has been used to construct a model of the ligand-binding domain of the sweet taste receptor, and low-resolution docking has been used to identify potential modes of brazzein-receptor binding. Published brazzein mutation-taste data were then used to select one of these as the most likely brazzein-receptor binding orientation. This orientation places brazzein in contact primarily with the T1R2 subunit of the receptor, and it accounts f ...[more]
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