Localizing organomercury uptake and accumulation in zebrafish larvae at the tissue and cellular level.
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ABSTRACT:
SUBMITTER: Korbas M
PROVIDER: S-EPMC2527873 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
Localizing organomercury uptake and accumulation in zebrafish larvae at the tissue and cellular level.
Korbas Malgorzata M Blechinger Scott R SR Krone Patrick H PH Pickering Ingrid J IJ George Graham N GN
Proceedings of the National Academy of Sciences of the United States of America 20080821 34
Using synchrotron x-ray fluorescence mapping, we have examined the uptake and localization of organic mercury in zebrafish larvae. Strikingly, the greatest accumulation of methyl and ethyl mercury compounds was highly localized in the rapidly dividing lens epithelium, with lower levels going to brain, optic nerve, and various other organs. The data suggest that the reported impairment of visual processes by mercury may arise not only from previously reported neurological effects, but also from d ...[more]
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