Ontology highlight
ABSTRACT:
SUBMITTER: Imanishi Y
PROVIDER: S-EPMC2529016 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Imanishi Yoshikazu Y Sun Wenyu W Maeda Tadao T Maeda Akiko A Palczewski Krzysztof K
The Journal of biological chemistry 20080707 36
The retinal pigmented epithelium (RPE) plays an essential role in vision, including storing and converting retinyl esters of the visual chromophore, 11-cis-retinal. Retinyl ester storage structures (RESTs), specialized lipid droplets within the RPE, take up retinyl esters synthesized in the endoplasmic reticulum. Here we report studies of mice lacking exons 2 and 3 of the gene encoding adipose differentiation-related protein (Adfp), a structural component of RESTs. We found that dark adaptation ...[more]