Ontology highlight
ABSTRACT:
SUBMITTER: Yu W
PROVIDER: S-EPMC2529350 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
EMBO reports 20080725 9
In multicellular epithelial tissues, the orientation of polarity of each cell must be coordinated. Previously, we reported that for Madin-Darby canine kidney cells in three-dimensional collagen gel culture, blockade of beta1-integrin by the AIIB2 antibody or expression of dominant-negative Rac1N17 led to an inversion of polarity, such that the apical surfaces of the cells were misorientated towards the extracellular matrix. Here, we show that this process results from the activation of RhoA. Kno ...[more]