Ontology highlight
ABSTRACT:
SUBMITTER: Brummer T
PROVIDER: S-EPMC2529372 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Brummer Tilman T Larance Mark M Herrera Abreu Maria Teresa MT Lyons Ruth J RJ Timpson Paul P Emmerich Christoph H CH Fleuren Emmy D G ED Lehrbach Gillian M GM Schramek Daniel D Guilhaus Michael M James David E DE Daly Roger J RJ
The EMBO journal 20080901 17
Grb2-associated binder (Gab)2 functions downstream of a variety of receptor and cytoplasmic tyrosine kinases as a docking platform for specific signal transducers and performs important functions in both normal physiology and oncogenesis. Gab2 signalling is promoted by its association with specific receptors through the adaptor Grb2. However, the molecular mechanisms that attenuate Gab2 signals have remained unclear. We now demonstrate that growth factor-induced phosphorylation of Gab2 on two re ...[more]