Efficient synthesis of 5-amido-3-hydroxy-4-pyrones as inhibitors of matrix metalloproteinases.
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ABSTRACT:
SUBMITTER: Yan YL
PROVIDER: S-EPMC2531216 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
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Efficient synthesis of 5-amido-3-hydroxy-4-pyrones as inhibitors of matrix metalloproteinases.
Yan Yi-Long YL Cohen Seth M SM
Organic letters 20070524 13
3-hydroxy-4-pyrones are a class of important metal chelators with versatile medicinal applications. An efficient pathway for the preparation of new 5-amido-3-hydroxy-4-pyrone derivatives has been developed. The synthesized 5-amido-3-hydroxy-4-pyrones have been evaluated as inhibitors of matrix metalloproteinases. ...[more]
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