Ontology highlight
ABSTRACT:
SUBMITTER: McNeill E
PROVIDER: S-EPMC2531226 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Organic letters 20060901 20
We report an improved synthesis of 5-(5-oxohexahydrocyclopenta[c]thiophen-1-yl)pentanoic acid (ketone biotin, 1) based on the intramolecular Pauson-Khand cyclization. The synthesis proceeds in eight steps and in 2.7% overall yield from cyclohexene. ...[more]