Ontology highlight
ABSTRACT:
SUBMITTER: Innocenti R
PROVIDER: S-EPMC7034245 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20200212
The Cu-catalyzed multicomponent ketone-amine-alkyne (KA<sup>2</sup>) reaction was combined with a Pauson-Khand cycloaddition to give access of unprecedented constrained spirocyclic pyrrolocyclopentenone derivatives following a DOS couple-pair approach. The polyfunctional molecular scaffolds were tested on the cyclopentenone reactivity to further expand the skeletal diversity, demonstrating the utility of this combined approach in generating novel spiro compounds as starting material for the gene ...[more]